PReS-FINAL-2153: Intestinal gamma/delta- T cells are upregulated in children with active uveitis
نویسندگان
چکیده
Introduction In experimental uveitis, activated g/δT lymphocytes produce cytokines, which contribute to differentiation of pathogenic effector T cells. In addition mucosal tolerance in experimental uveitis can be induced by introducing uveitogenic retinal soluble antigen orally and this phenomenon is dependent on g/δ T cells. The major reservoir for g/δT cells is intestinal mucosa, where they function in safeguarding the integrity of the epithelial barrier. Abnormal activation of these intraepithelial g/δT-cells may contribute to immunopathological responses which can even present themselves as extraintestinal manifestations. ANA-positive in JIA is associated both with uveitis and accumulation of g/δT cells with gut-associated subtype in synovium.
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